The Detroit Lions and San Francisco 49ers are scheduled to meet up in Week 2 of the 2012 NFL regular season on Sept. 16th, with the opening kickoff from Candlestick Park scheduled for 8:20 p.m. ET on NBC's Sunday Night Football.
Cantor Gaming has released the 49ers as 3.5-point home favorites, as the contest will receive plenty of media attention due to last year's end-of-game handshake between San Francisco head coach Jim Harbaugh and Detroit head coach Jim Schwartz.
San Francisco came away with a 25-19 win as 5.5-point road underdogs in Week 6 of last year, while the score fell just under the posted total of 45. The 49ers fell behind by 10 points after the first quarter, but rallied by ultimately out-gaining the Lions by 137 yards on the ground.
49ers running back ...
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